gsDesign2: Group Sequential Design with Non-Constant Effect
The goal of 'gsDesign2' is to enable fixed or group sequential design under non-proportional hazards. To enable highly flexible enrollment, time-to-event and time-to-dropout assumptions, 'gsDesign2' offers piecewise constant enrollment, failure rates, and dropout rates for a stratified population. This package includes three methods for designs: average hazard ratio, weighted logrank tests in Yung and Liu (2019) <doi:10.1111/biom.13196>, and MaxCombo tests. Substantial flexibility on top of what is in the 'gsDesign' package is intended for selecting boundaries.
| Version: | 1.1.6 |
| Depends: | R (≥ 4.1.0) |
| Imports: | corpcor, data.table, dplyr, gsDesign, gt, methods, mvtnorm, npsurvSS (≥ 1.1.0), r2rtf, stats, survival, tibble, tidyr, utils, Rcpp |
| LinkingTo: | Rcpp |
| Suggests: | covr, ggplot2, kableExtra, knitr, rmarkdown, simtrial, testthat (≥ 3.0.0) |
| Published: | 2025-09-11 |
| DOI: | 10.32614/CRAN.package.gsDesign2 |
| Author: | Keaven Anderson [aut],
Yujie Zhao [aut, cre],
Yilong Zhang [aut],
John Blischak [aut],
Yihui Xie [aut],
Nan Xiao [aut],
Jianxiao Yang [aut],
Amin Shirazi [ctb],
Ruixue Wang [ctb],
Yi Cui [ctb],
Ping Yang [ctb],
Xin Tong Li [ctb],
Chenxiang Li [ctb],
Hiroaki Fukuda [ctb],
Hongtao Zhang [ctb],
Yalin Zhu [ctb],
Shiyu Zhang [ctb],
Dickson Wanjau [ctb],
Merck & Co., Inc., Rahway, NJ, USA and its affiliates
 [cph] |
| Maintainer: | Yujie Zhao <yujie.zhao at merck.com> |
| BugReports: | https://github.com/Merck/gsDesign2/issues |
| License: | GPL-3 |
| URL: | https://merck.github.io/gsDesign2/, https://github.com/Merck/gsDesign2 |
| NeedsCompilation: | yes |
| Materials: | README, NEWS |
| CRAN checks: | gsDesign2 results |
Documentation:
| Reference manual: | gsDesign2.html , gsDesign2.pdf |
| Vignettes: |
Quick start for NPH sample size and power (source, R code) |
Downloads:
| Package source: | gsDesign2_1.1.6.tar.gz |
| Windows binaries: | r-devel: gsDesign2_1.1.5.zip, r-release: gsDesign2_1.1.5.zip, r-oldrel: gsDesign2_1.1.5.zip |
| macOS binaries: | r-release (arm64): gsDesign2_1.1.6.tgz, r-oldrel (arm64): gsDesign2_1.1.6.tgz, r-release (x86_64): gsDesign2_1.1.6.tgz, r-oldrel (x86_64): gsDesign2_1.1.5.tgz |
| Old sources: | gsDesign2 archive |
Reverse dependencies:
| Reverse suggests: | simtrial |
Linking:
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